| Measure | Variables included | Type of pain | Psychometric testing |
| PIPP (Premature Infant Pain Profile)* | Heart rate, oxygen saturation, facial actions; takes state and gestational age into account | Procedural, postoperative (minor) | Reliability, validity, clinical utility well established |
| NIPS (Neonatal Infant Pain Score) | Facial expression, crying, breathing patterns, arm and leg movements, arousal | Procedural | Reliability, validity |
| NFCS (Neonatal Facial Coding System) | Facial actions | Procedural | Reliability, validity, clinical utility, high degree of sensitivity to analgesia |
| N-PASS (Neonatal Pain, Agitation, and Sedation Scale) | Crying, irritability, behavioral state, facial expression, extremity tone, vital signs | Postoperative, procedural, ventilated | Reliability, validity, includes sedation end of scale, does not distinguish pain from agitation |
| CRIES (Cry, Requires oxygen, Increased vital signs, Expression, Sleeplessness) | Crying, facial expression, sleeplessness, requires oxygen to stay at >95% saturation, increased vital signs | Postoperative | Reliability, validity |
| COMFORT scale | Movement, calmness, facial tension, alertness, respiration rate, muscle tone, heart rate, blood pressure | Postoperative, critical care, developed for sedation, recently validated for postoperative pain in 0- to 3-year-old infants | Reliability, validity, clinical utility |
| Douleur Aiguë Nouveau-né scale | Facial and limb movements, vocal expression | Procedural pain | Reliability, validity |
| Behavioral Infant Pain Profile | Behavioral state, facial expression and hand movements | Acute pain | Reliability, validity |
