Test result | Causes of test result pattern |
PT | aPTT |
Prolonged | Normal | Inherited |
Factor VII deficiency |
Acquired |
Mild vitamin K deficiency |
Liver disease |
Warfarin* |
DIC |
Normal | Prolonged | Inherited |
Deficiency of factor VIII, IX, or XI |
Deficiency of factor XII, prekallikrein, or HMW kininogen (not associated with a bleeding diathesis) |
von Willebrand disease (variable) |
Acquired |
Heparin, dabigatran, argatroban, direct factor Xa inhibitors (variable)* |
Acquired inhibitor of factor VIII, IX, XI, or XII |
Acquired von Willebrand syndrome |
Lupus anticoagulant (more likely to be associated with thrombosis than bleeding) |
Prolonged | Prolonged | Inherited |
Deficiency of prothrombin, fibrinogen, factor V, or factor X |
Combined factor deficiencies |
Acquired |
Liver disease |
DIC |
Severe vitamin K deficiency |
Anticoagulants (supratherapeutic doses of many anticoagulants, combined heparin and warfarin, direct thrombin inhibitors, anticoagulant rodenticide poisoning)* |
Acquired inhibitor of prothrombin, fibrinogen, factor V, or factor X |
Amyloidosis-associated factor X deficiency |