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Substances that interfere with determination of urinary 5-HIAA

Substances that interfere with determination of urinary 5-HIAA
Falsely high values
Tryptophan-rich foods: avocados, pineapples, bananas, kiwi fruit, plums, eggplants, walnuts, hickory nuts, pecans, tomatoes, plantains, butternut squash
Drugs: acetaminophen, coumaric acid, guaifenesin, mephenesin, phenobarbital, reserpine, acetanilid, ephedrine, methamphetamine, nicotine, phentolamine, phenmetrazine, caffeine, fluorouracil, melphalan, methocarbamol, phenacetin, mesalamine
Falsely low values
Drugs: corticotrophin, ethanol, imipramine, levodopa, MAO inhibitors, phenothiazines, aspirin, isoniazid, gentisic acid, methenamine, streptozotocin, heparin, methyldopa
5-HIAA: 5-hydroxyindoleacetic acid; MAO: monoamine oxidase.
Reference:
  1. Corcuff J, Chardon L, El Hajji Ridah I, Brossaud J. Urinary sampling for 5HIAA and metanephrines determination: revisiting the recommendations. Endocr Connect 2017; 6:R87.
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