Platelet count and platelet survival in megakaryocyte disorders

Platelet kinetic studies were performed in normal subjects and patients with a variety of hematological conditions: hypoplastic bone marrow states (Hypo), B12 deficiency (B12 def), congestive splenomegaly (Congest), immune thrombocytopenia (ITP), chronic inflammation (Inflam), and essential thrombocythemia (ET). Left panel: The median platelet counts were greater than normal only in inflammatory conditions and ET. Right panel: Platelet survival was significantly different from normal only in ITP.