Immunogenicity of candidate conjugate vaccines against Group B streptococcus in healthy women of childbearing age

Type Ia-TT and Ib-TT conjugate vaccines were well tolerated by healthy, childbearing-age women, and the serotype-specific IgG response was significantly greater in recipients of the conjugate compared with the uncoupled CPS vaccine. Subjects were randomized to receive (panel A) Ia-TT vaccine (red line, n = 30), uncoupled Ia CPS (blue line, n = 30), or saline placebo (green line, n = 15); or (panel B) Ib-TT vaccine (red line, n = 30), uncoupled Ib CPS (blue line, n = 15), or saline placebo (green line, n = 10).