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Classic Li-Fraumeni syndrome^[1] - Diagnostic criteria

All of the following:

• A proband with sarcoma diagnosed before age 45 years

• A first-degree relative with any cancer before age 45 years

• A first- or second-degree relative with any cancer before age 45 years or a sarcoma at any age

Reference:

Li FP, Fraumeni JF, Mulvihill JJ, et al. A cancer family syndrome in twenty-four kindreds. Cancer Res 1988; 48:5358.

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Classic Li-Fraumeni syndrome[1] - Diagnostic criteria