| Ill or medicated individual |
| 1. Drugs |
| Insulin or insulin secretagogue |
| Alcohol |
| Others (refer to UpToDate table on drugs that cause hypoglycemia) |
| 2. Critical illnesses |
| Hepatic, renal, or cardiac failure |
| Sepsis (including malaria) |
| Inanition |
| 3. Hormone deficiency |
| Cortisol |
| Glucagon and epinephrine (in insulin-deficient diabetes mellitus) |
| 4. Nonislet cell tumor |
| Seemingly well individual |
| 5. Endogenous hyperinsulinism |
| Insulinoma |
| Functional beta cell disorders (nesidioblastosis) |
| Noninsulinoma pancreatogenous hypoglycemia |
| Post-gastric bypass hypoglycemia |
| Insulin autoimmune hypoglycemia |
| Antibody to insulin |
| Antibody to insulin receptor |
| Insulin secretagogue |
| Other |
| 6. Accidental, surreptitious, or malicious hypoglycemia |
