| Drug | Side effects* |
| Brivaracetam¶ | Hypersensitivity reactions including bronchospasm and angioedema, leukopenia, neutropenia, psychosis |
| Cannabidiol | Hypersensitivity reactions (including angioedema, erythema, and pruritus), suicidal ideation |
| Carbamazepine | Agranulocytosis, aplastic anemia, SJS/TEN, hepatic failure, DRESS, dermatitis/rash, serum sickness, pancreatitis, lupus syndrome, hypogammaglobulinemia |
| Cenobamate | QT interval shortening, DRESS/multiorgan hypersensitivity |
| Clobazam | Respiratory depression, SJS/TEN, DRESS |
| Eslicarbazepine | Prolonged PR interval, atrioventricular block, hyponatremia (rarely severe), SJS/TEN |
| Ethosuximide | Agranulocytosis, SJS/TEN, aplastic anemia, hepatic failure, dermatitis/rash, serum sickness, drug-induced immune thrombocytopenia |
| Felbamate | Aplastic anemia, liver failure |
| Gabapentin | Multiorgan hypersensitivity, respiratory depression |
| Lacosamide | Prolonged PR interval, atrioventricular block, multiorgan hypersensitivity, neutropenia |
| Lamotrigine | SJS/TEN, DRESS/multiorgan hypersensitivity, aseptic meningitis, hypogammaglobulinemia, cardiac rhythm and conduction abnormalities |
| Levetiracetam | SJS/TEN, anaphylaxis and angioedema, pancytopenia, psychosis, hypogammaglobulinemia |
| Oxcarbazepine | SJS/TEN, DRESS/multiorgan hypersensitivity, agranulocytosis, pancytopenia, leukopenia |
| Perampanel | Severe neuropsychiatric effects (eg, hostility, aggression) |
| Phenobarbital | Agranulocytosis, SJS/TEN, hepatic failure, dermatitis/rash, serum sickness, connective tissue contractures (eg, Dupuytren) |
| Phenytoin | Agranulocytosis, SJS/TEN, DRESS, aplastic anemia, hepatic failure, dermatitis/rash, serum sickness, adenopathy, pseudolymphoma, neuropathy, ataxia, lupus syndrome, hirsutism |
| Pregabalin | Angioedema, hypersensitivity reactions, rhabdomyolysis |
| Primidone | Acute toxic reaction (sedation, dizziness, ataxia, nausea, and vomiting), agranulocytosis, SJS/TEN, hepatic failure, dermatitis/rash, serum sickness, connective tissue contractures (eg, Dupuytren) |
| Rufinamide | SJS/TEN, DRESS, dermatitis/rash, shortened QT interval |
| Stiripentol | Limited information: severe somnolence, marked weight loss, neutropenia and thrombocytopenia, suicidal ideation and behavior |
| Tiagabine | SJS/TEN, nonconvulsive status epilepticus |
| Topiramate | Acute myopia and glaucoma, kidney stones, oligohidrosis and hyperthermia (which primarily occur in children) |
| Valproate | Agranulocytosis, SJS/TEN, aplastic anemia, hepatic failure, dermatitis/rash, serum sickness, pancreatitis, polycystic ovary syndrome, hypogammaglobulinemia |
| Vigabatrin | MRI abnormalities, depression, weight gain |
| Zonisamide | Rash, SJS/TEN, aplastic anemia, agranulocytosis, nephrolithiasis; acute myopia and secondary angle closure glaucoma, hyperammonemia and encephalopathy; in children, fever and hyperhidrosis |
SJS: Stevens-Johnson syndrome; TEN: toxic epidermal necrolysis; DRESS: drug reaction with eosinophilia and systemic symptoms; MRI: magnetic resonance imaging.
* As a class, antiseizure medications have been associated with an increased risk of suicidal ideation and suicidal behavior.
¶ Based upon limited experience from preapproval clinical trials.