Optimal INR for minimizing bleeding and thromboembolism when using oral anticoagulation

This figure shows the relative risks and their 95 percent confidence intervals for the occurrence of thromboembolism (closed circles, confidence intervals in yellow) and hemorrhage (open circles, confidence intervals in blue) as a function of the INR range in patients prescribed oral anticoagulant therapy. The comparator for both end-points is the INR range of 2.0 to 3.0 (ie, relative risk of 1.0). Note that hemorrhagic risk becomes dominant at an INR >3, while thromboembolic risk is dominant at an INR <2.