Aggressive BP control preserves kidney function in proteinuric patients

Mean fall in glomerular filtration rate (GFR) according to the degree of proteinuria in patients treated with usual BP control (mean BP about 130/80 mmHg) or with more aggressive antihypertensive therapy in which the mean BP was 4.7 mmHg lower over a 3-year period. The rate of fall in GFR varied directly with protein excretion, and the benefit of aggressive BP control was absent in the 420 patients excreting less than 1 g/day, modest in the 104 patients excreting between 1 and 3 g/day, and substantial (3.5 mL/min/year slower) and statistically significant in the 54 patients excreting at least 3 g/day.