Initial fasting blood glucose concentration determines degree of weight loss required to achieve normoglycemia in type 2 diabetes

Glycemic response to weight reduction according to initial fasting blood glucose (in mmol/L) in type 2 diabetes. Patients who had mildly elevated fasting blood glucose concentrations of 6 to 8 mmol/L (108 to 144 mg/dL) initially had to lose 10 kg (16 percent of initial body weight) to achieve a value below 6 mmol/L (<108 mg/dL). Greater degrees of weight loss were required in patients with higher initial values, rising to 26 kg and 41 percent, respectively, in patients with an initial value above 14 mmol/L (>252 mg/dL).