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The role of endomyocardial biopsy in fourteen clinical scenarios

The role of endomyocardial biopsy in fourteen clinical scenarios
Scenario number Clinical scenario Class of recommendation (I, IIa, IIb, III) Level of evidence (A,B,C)
1 New onset heart failure of less than 2 weeks duration associated with a normal size or dilated left ventricle and hemodynamic compromise I B
2 New onset heart failure of 2 weeks to 3 months duration associated with a dilated left ventricle, and new ventricular arrhythmias, second or third degree heart block, or failure to respond to usual care within 1 to 2 weeks I B
3 Heart failure of greater than 3 months duration associated with a dilated left ventricle and new ventricular arrhythmias, second or third degree heart block, or failure to respond to usual care within 1 to 2 weeks IIa C
4 Heart failure associated with a dilated cardiomyopathy of any duration associated with suspected allergic reaction and/or eosinophilia IIa C
5 Heart failure associated with suspected anthracycline cardiomyopathy IIa C
6 Heart failure associated with unexplained restrictive cardiomyopathy IIa C
7 Suspected cardiac tumors IIa C
8 Unexplained cardiomyopathy in children IIa C
9 New onset heart failure of 2 weeks to 3 months duration associated with a dilated left ventricle, without new ventricular arrhythmias, or second or third degree heart block, and that responds to usual care within 1 to 2 weeks IIb B
10 Heart failure of greater than 3 months duration associated with a dilated left ventricle, without new ventricular arrhythmias, or second or third degree heart block, and that responds to usual care within 1 to 2 weeks IIb C
11 Heart failure associated with unexplained hypertrophic cardiomyopathy IIb C
12 Suspected arrhythmogenic right ventricular dysplasia/cardiomyopathy IIb C
13 Unexplained ventricular arrhythmias IIb C
14 Unexplained atrial fibrillation III C
Endo_biopsy_recs.htm
Reproduced with permission from: Cooper, LT, Baughman, KL, Feldman, AM, et al. The role of endomyocardial biopsy in the management of cardiovascular disease: a scientific statement from the American Heart Association, the American College of Cardiology, and the European Society of Cardiology. Circulation 2007; 116:2216. Copyright ©2007 Lippincott Williams and Wilkins.
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