Oral treatment regimens for autoimmune hepatitis in adults^[1]

* Orally administered prednisolone can be used in place of prednisone at the same doses. For patients with mild disease (eg, asymptomatic patients with aminotransferase levels <10 times the upper limit of normal), lower dose prednisone monotherapy (20 mg per day) is an alternative. 
¶ For patients on prednisone monotherapy for induction, the initial prednisone dose is typically 40 to 60 mg daily. In patients at increased risk of side effects from glucocorticoids, a lower dose of prednisone monotherapy (eg, 30 mg daily) or combination therapy may be preferable to prednisone monotherapy.
Δ TPMT phenotyping should be obtained before initiating azathioprine. In Europe, an azathioprine dose of 1 to 2 mg/kg/day is often used.
◊ Prednisone may be further tapered to an individual dose that maintains remission. A 10 mg/day maintenance dose may be achieved by tapering the dose by 5 mg every week. A maintenance dose of 5 mg/day may be considered; in that case, the dose is tapered by 2.5 mg every week. The maintenance prednisone regimen is continued until resolution of the disease, treatment failure, or drug-intolerance.
§ Prednisone may be further tapered to an individual dose that maintains remission by increments of 2.5 mg/day each week down to a dose of 5 mg/day. Dose adjustment recommendations for maintenance with either azathioprine or glucocorticoids alone are provided in the topic and accompanying algorithm.