Your activity: 38 p.v.
< Back
your limit has been reached. plz Donate us to allow your ip full access, Email: sshnevis@outlook.com

Molecular classification of colorectal carcinoma

Molecular classification of colorectal carcinoma
  Chromosomal instability pathway (APC) Mismatch repair pathway Serrated pathway
Hereditary (FAP) and sporadic Hereditary Hereditary Sporadic
CIMP status Negative Negative High High
MSI status MSS MSI-H MSI-H MSI-L
Chromosomal instability +++ --- --- ---
KRAS mutation +++ +/- --- ---
BRAF mutation --- --- +++ +++
MLH1 status Normal Mutation Methylated Partial methylation
CIMP: CpG island methylator phenotype; MSS: microsatellite stability; MSI: microsatellite instability; MSI-H: high-level microsatellite instability; MSI-L: low-level microsatellite instability; +++: present; +/-: might or might not be present; ---: absent.
Reproduced from: Cunningham, D, Atkins, W, Lenz, HJ, et al. Colorectal cancer. Lancet 2010; 375:1030. Copyright © 2010. Illustration used with the permission of Elsevier Inc. All rights reserved.
Graphic 77353 Version 5.0