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Representative example of in situ hybridization of nasal biopsy specimens in allergic rhinitis

Representative example of in situ hybridization of nasal biopsy specimens in allergic rhinitis
Expression of IL-4 mRNA after antigen challenge (A) and diluent challenge (B). Expression of IL-14 mRNA after allergen challenge and (C) colocalization of IL-4 and IL-13 mRNA after allergen challenge (D).
IL: interleukin; mRNA: messenger RNA.
Reproduced with permission from: Christodoulopoulos P, Cameron L Durham S, Hamid Q. Molecular pathology of allergic disease. II: Upper airway disease. J Allergy Clin Immunol 2000; 105(2 Pt 1):211. Copyright © 2000 Elsevier.
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