| Intravenous premedication regimen |
| Premedications (last dose immediately prior to infusion of chemotherapy) |
| Dexamethasone, 10-20 mg iv every 6 hours for 4 doses |
| Cimetidine, 300 mg iv every 8 hours for 3 doses |
| Diphenhydramine hydrochloride, 25-50 mg iv every 6 hours for 4 doses |
| Optional |
| Ondansetron hydrochloride (Zofran), 8 mg iv every 6 hours for 4 doses |
| Albuterol nebulizer, 2.5 mg every 6 hours for 4 doses |
| Oral premedication regimen |
| Premedications |
| Dexamethasone, 20 mg po every 6 hours for 4 to 8 doses |
| Cimetidine, 300-600 mg po every 8 hours for 3 to 6 doses |
| Diphenhydramine hydrochloride, 25-50 mg every 6 hours for 4 to 8 doses |
| Optional |
| Albuterol multidose inhaler, two puffs administered every 6 hours for 8 doses |
| Immediately prior to infusion of chemotherapy |
| Dexamethasone, 20 mg iv |
| Cimetidine, 300-600 mg iv |
| Diphenhydramine hydrochloride, 25-50 mg iv |
| Optional |
| Lorazepam, 0.5 mg iv |
| Ondansetron hydrochloride, 8 mg iv |
| May continue dexamethasone, cimetidine, diphenhydramine during infusion |
