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In a patient with preeclampsia, the presence of one or more of the following indicates a diagnosis of "preeclampsia with severe features"

In a patient with preeclampsia, the presence of one or more of the following indicates a diagnosis of "preeclampsia with severe features"
Severe blood pressure elevation:
Systolic blood pressure ≥160 mmHg and/or diastolic blood pressure ≥110 mmHg on 2 occasions at least 4 hours apart while the patient is on bedrest; however, antihypertensive therapy generally should be initiated upon confirmation of severe hypertension, in which case criteria for severe blood pressure elevation can be satisfied without waiting until 4 hours have elapsed
Symptoms of central nervous system dysfunction:
New-onset cerebral or visual disturbance, such as:
  • Photopsia, scotomata, cortical blindness, retinal vasospasm
  • Severe headache (ie, incapacitating, "the worst headache I've ever had") or headache that persists and progresses despite analgesic therapy with acetaminophen and not accounted for by alternative diagnoses
Hepatic abnormality:
Impaired liver function not accounted for by another diagnosis and characterized by serum transaminase concentration >2 times the upper limit of the normal range or severe persistent right upper quadrant or epigastric pain unresponsive to medication and not accounted for by an alternative diagnosis
Thrombocytopenia:
<100,000 platelets/microL
Renal abnormality:
Renal insufficiency (serum creatinine >1.1 mg/dL [97.2 micromol/L] or a doubling of the serum creatinine concentration in the absence of other renal disease)
Pulmonary edema
Reference:
  1. American College of Obstetricians and Gynecologists (ACOG) Practice Bulletin No. 222: Gestational Hypertension and Preeclampsia. Obstet Gynecol 2020; 135:e237.
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