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Uptodate Reference Title
Hypergranular variant of acute promyelocytic leukemia
Hypergranular variant of acute promyelocytic leukemia
The malignant promyelocytes in the more common "hypergranular" variant of acute promyelocytic leukemia (APL) have characteristic large reddish-blue or dark purple granules in the cytoplasm. The nucleus is often folded, indented, or dumb-bell shaped.