Mechanism of proteinuria in FGS

Dextran sieving profiles in patients with heavy proteinuria and the nephrotic syndrome due to focal glomerulosclerosis (FGS). A fractional dextran clearance of 1 represents complete filtration. Patients with FGS have decreased clearance of smaller dextrans, but increased clearance of dextrans with a radius above 52 Å, suggesting an increased number of larger pores.