| Diamond-Blackfan anemia | Transient erythroblastopenia of childhood | |
| Age | Classically presents in infancy | Presents at age 1 to 4 years |
| Preceding viral illness | No | Yes |
| Nonhematologic abnormalities | Approximately 50% have associated congenital abnormalities (eg, craniofacial abnormalities, thumb anomalies), growth failure, and/or developmental delays | Absent |
| Laboratory findings | ||
| Type of anemia | Usually macrocytic | Usually normocytic* |
| Reticulocyte count | Low | Low |
| Hemoglobin F | Increased | Normal |
| eADA activity | Elevated | Normal |
| Course | Progressive anemia with most patients requiring prolonged transfusion support or steroid therapy | Spontaneous recovery within weeks to months |
