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Efficacy of higher concentrations of beta-lactams against penicillin-resistant pneumococci

Efficacy of higher concentrations of beta-lactams against penicillin-resistant pneumococci
More effective Less effective
Penicillins Penicillins
Penicillin, amoxicillin Ticarcillin
Piperacillin Cephalosporins
Cephalosporins First generation
Second generation
  • Cefazolin, cephalexin
  • Cefuroxime
 Second generation
Third generation
  • Cefaclor
  • Cefotaxime
 Third generation
  • Ceftriaxone
  • Ceftazidime
  • Cefpodoxime
  • Cefixime
Fourth generation Carbapenems
  • Cefepime
 Ertapenem
Fifth generation  
  • Ceftaroline
Carbapenems
Imipenem-cilastatin
Graphic 76028 Version 2.0