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Sensitivity and specificity of antibody tests for celiac disease in children

Sensitivity and specificity of antibody tests for celiac disease in children
  Sensitivity (percent) Specificity (percent)
Tissue transglutaminase; tTG (IgA, human)[1-3] 90 to 100 95 to 100
Anti-endomysial antibody (IgA)[1] 93 to 100 98 to 100
Deamidated gliadin peptide; DGP (IgA)*[4] 80 to 91 91 to 95
Deamidated gliadin peptide; DGP (IgG)*[4] 88 to 95 86 to 98
Anti-gliadin antibody IgA[1]  52 to 100  72 to 100 
Anti-gliadin antibody IgG[1]  83 to 100  47 to 94 
tTG: tissue transglutaminase; IgA: immunoglobulin A; DGP: deamidated gliadin peptide; IgG: immunoglublin G.
* Sensitivity and specificity of DGP may be better in children younger than 2 years of age as compared with tTG or anti-endomysial antibodies[5].
References
  1. Hill, ID. What are the sensitivity and specificity of serologic tests for celiac disease? Do sensitivity and specificity vary in different populations? Gastroenterology 2005; 128 (4 Suppl 1):S25
  2. Basso, D, Guariso, G, Fasolo, M, et al. A new indirect chemiluminescent immunoassay to measure anti-tissue transglutaminase antibodies. J Pediatr Gastroenterol Nutr 2006; 43:613.
  3. Lewis NR, Scott BB. Meta-analysis: deamidated gliadin peptide antibody and tissue transglutaminase antibody compared as screening tests for coeliac disease. Aliment Pharmacol Ther 2010; 31:73.
  4. Agardh D. Antibodies against synthetic deamidated gliadin peptides and tissue transglutaminase for the identification of childhood celiac disease. Clin Gastroenterol Hepatol 2007; 5:1276.
  5. Mubarak A, Gmelig-Meyling FHJ, Wolters VM et al. Immunoglobulin G antibodies against deamidated-gliadin-peptides outperform anti-endomysium and tissue transglutaminase antibodies in children <2 years age. APMIS 2011; 119:894.
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