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Oral antibiotics for treatment of travelers' diarrhea in adults

Oral antibiotics for treatment of travelers' diarrhea in adults
Agent Dose Duration Comment
Azithromycin 1000 mg once Single dose*
  • Preferred for dysentery or febrile diarrhea, travelers from Southeast Asia, and pregnant women.
  • The 1000 mg dose may be associated with nausea.
500 mg once daily 3-day course
Rifaximin 200 mg 3 times daily 3-day course
  • Not for use with dysentery or febrile diarrhea.
Rifamycin 2 (194 mg) tablets twice daily 3-day course
Levofloxacin 500 mg once daily Single dose* or 3-day course
  • Fluoroquinolones are associated with multiple adverse events.
  • Resistance to fluoroquinolones in enteric pathogens is increasing worldwide, limiting their utility.
Ciprofloxacin 750 mg once Single dose*
500 mg twice daily 3-day course
Ofloxacin 400 mg once daily Single dose* or 3-day course
* If symptoms have not resolved after 24 hours, the regimen can be extended to complete a 3-day course (using the dosing listed for the 3-day course).
Riddle MS, Connor BA, Beeching NJ, et al. Guidelines for the prevention and treatment of travelers' diarrhea: a graded expert panel report. J Travel Med 2017; 24:S57.
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