Hb S polymer formation |
Sickle cell deformability |
Sickle cell whole blood viscosity |
Fraction of dense irreversibly sickled cells |
Red blood cell function |
Sickle cell adherence to vascular endothelium |
Endothelial cell activation |
Mast cell activation |
Hemostatic activation |
Platelet activation |
White blood cell numbers and activity |
Vasoregulatory factors |
Vascular architecture |
Environmental factors |
Psychosocial adaptation |