Importance of genetic markers in susceptibility to type 1 diabetes

Genetic marker	No relatives with type 1 diabetes	First-degree relative with type 1 diabetes
DQB0302/0201	1 in 25	1 in 4
DQB0302/0302	1 in 60	1 in 10
DQB0302/0602	1 in 1500	Unknown
DQB*0302/Other	1 in 60	1 in 10
DQB0201/0201	1 in 350	1 in 10
DQB0201/Other	1 in 400	1 in 20
Other	1 in 5000	1 in 40

Risk estimates for susceptibility to type 1 diabetes in White people according to presence or absence of type 1 diabetes susceptibility genes and family history. DQB*0302 and DQB*0201 are associated with high susceptibility, while DQB*0602 is a protective gene. The risk is highest in patients who are heterozygous for both high-susceptibility genes (DQB*0302 and DQB*0201).

Data from: Atkinson MA, Maclaren NK. The pathogenesis of insulin-dependent diabetes mellitus. N Engl J Med 1994; 331:1428.

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