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Major causes of primary ovarian insufficiency (premature ovarian failure) in women

Major causes of primary ovarian insufficiency (premature ovarian failure) in women
Accelerated follicular atresia
Genetic defects
Turner syndrome
Fragile X premutations
X chromosome deletions and translocations
Galactosemia
Ovarian toxins
Chemotherapeutic drugs (especially alkylating agents)
Radiation
Mumps or cytomegalovirus infection
Autoimmune injury
Isolated or part of polyglandular autoimmune syndromes
Abnormal follicular stimulation
Intraovarian modulators
BMP15
Steroidogenic enzyme defects
CYP17 deficiency, StAR mutation
Aromatase gene mutations
Gonadotropin receptor function
FSH receptor mutations
Gs alpha subunit gene mutations
FSH: follicle-stimulating hormone.
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