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Hemofiltration sieving coefficients for drugs

	SC	Unbound fraction		SC	Unbound fraction
Antimicrobials			Other drugs
Acyclovir	0.9	0.9	Cyclosporine	0.6	0.1
Amikacin	0.9	0.9	Diazepam	0.02	0.02
Amphotericin	0.3	0.1	Digitoxin	0.9	0.8
Ampicillin	0.7	0.8	Digoxin	0.9	0.8
Cefepime	0.9	0.8	Famotidine	0.7	0.8
Cefoperazone	0.3	0.1	Glutethimide	0.02	0.5
Cefoxitin	0.6	0.5	Lidocaine	0.2	0.4
Ceftazidime	0.9	0.9	Metamizole	0.4	0.4
Ciprofloxacin	0.8	0.7	Oxazepam	0.1	0.1
Daptomycin	0.1	0.1	Phenobarbital	0.8	0.6
Ganciclovir	0.9	1.0	Phenytoin	0.4	0.2
Gentamicin	0.8	0.9	Procainamide	0.9	0.9
Imipenem	1.0	0.8	Ranitidine*	0.8	0.8
Jazobactam	0.7	0.7	Theophylline	0.9	0.9
Levofloxacin	0.8	0.8
Linezolid	0.8	0.7
Meropenem	0.9	0.9
Metronidazole	0.8	0.8
Mezlocillin	0.7	0.7
Ofloxacin	0.3	0.7
Oxacillin	0.02	0.05
Penicillin	0.7	0.5
Piperacillin	0.7	0.7
Sulfamethoxazole	0.9	0.6
Tazobactam	0.7	0.7
Vancomycin	0.8	0.9

Sieving coefficient (SC) and unbound fraction for some commonly used drugs. There is usually a close correlation between these parameters because only the free or unbound drug is available for removal by hemofiltration.

* Withdrawn from the United States market for safety reasons.

Graphic 73902 Version 4.0