| Age >40 |
| Cardiac disease (heart failure, arrhythmia, angina, myocardial ischemia, recent myocardial infarction) |
| Hemodynamic instability |
| Marked acid-base disturbances |
| Severe electrolyte abnormalities (hypokalemia, hypophosphatemia, hypomagnesemia, hypocalcemia) |
| Respiratory insufficiency (hypoxemia, hypercapnia, severe hypocapnia, pneumonia, asthma, COPD) |
| Potentially serious infections (wounds, pneumonia, trauma, urinary tract infection) |
| Signs of gastrointestinal pathology (pancreatitis, GI bleeding, hepatic insufficiency, suspected peritonitis) |
| Persistent hyperthermia (T >39°C [103°F]) |
| Evidence of rhabdomyolysis |
| Renal insufficiency or increased fluid requirements |
| History of prior alcohol withdrawal complications (eg, delirium tremens, alcohol withdrawal seizures) |
| Need for frequent or high doses of sedatives or an intravenous infusion to control symptoms |
| Withdrawal despite an elevated ethanol concentration |
