| Definite IE is established in the presence of any of the following: |
| Pathologic criteria |
| Pathologic lesions – Vegetation or intracardiac abscess demonstrating active endocarditis on histology, OR |
| Microorganism – Demonstrated by culture or histology of a vegetation or intracardiac abscess |
| Clinical criteria |
| Using specific definitions listed in Table B: |
| 2 major clinical criteria, OR |
| 1 major and 3 minor clinical criteria, OR |
| 5 minor clinical criteria |
| Possible IE* |
| Presence of 1 major and 1 minor clinical criteria OR presence of 3 minor clinical criteria |
| Rejected IE |
| A firm alternate diagnosis is made, OR |
| Resolution of clinical manifestations occurs after ≤4 days of antibiotic therapy, OR |
| No pathologic evidence of infective endocarditis is found at surgery or autopsy after antibiotic therapy for 4 days or less |
| Clinical criteria for possible or definite IE not met |
