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Clinical findings in neonatal sepsis

Clinical findings in neonatal sepsis
Finding Frequency*
Hyperthermia +++
Respiratory distress +++
Tachycardia +++
Lethargy ++
Poor feeding ++
Apnea ++
Bradycardia ++
Poor perfusion/hypotension ++
Vomiting ++
Jaundice ++
Hepatomegaly ++
Cyanosis +
Hypothermia +
Irritability +
Seizures +
Abdominal distension +
Diarrhea +
* +++: commonly associated (≥50% of cases); ++: frequently associated (25 to 50%); +: occasionally associated (<25%).
References:
  1. Nizet V, Klein JO. Bacterial sepsis and meningitis. In: Infectious Diseases of the Fetus and Newborn Infant, 8th ed, Remington JS, Klein JO, Wilson CB, et al (Eds), Elsevier Saunders, 2016. p.411.
  2. Stoll BJ, Puopolo KM, Hansen NI, et al. Early-Onset Neonatal Sepsis 2015 to 2017, the Rise of Escherichia coli, and the Need for Novel Prevention Strategies. JAMA Pediatr 2020; 174:e200593.
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