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Uptodate Reference Title
Risk of venous thromboembolism associated with use of oral contraceptives, factor V leiden, and/or prothrombin gene mutation
Risk of venous thromboembolism associated with use of oral contraceptives, factor V leiden, and/or prothrombin gene mutation
OC Use*
Factor V Leiden
Factor II G20210A
Odds ratio¶
–
–
–
1
+
–
–
2.3
–
–
+
3.2
–
+
–
5.9
+
–
+
7.1
+
+
–
10.2
–
+
+
14.7
+
+
+
17
* Oral contraceptives; factor II is prothrombin. ¶ Crude odds ratio for risk of venous thromboembolism given the combination of risks (–: risk not present; +: risk present).
Adapted from: Emmerich J, Rosendaal FR, Cattaneo M, et al. Combined effect of factor V Leiden and prothrombin 20210A on the risk of venous thromboembolism--pooled analysis of 8 case-control studies including 2310 cases and 3204 controls. Study Group for Pooled-Analysis in Venous Thromboembolism. Thromb Haemost 2001; 86:809.
