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Aβ subgroups of ketosis-prone diabetes mellitus: Clinical characteristics and natural history

Aβ subgroups of ketosis-prone diabetes mellitus: Clinical characteristics and natural history
  A+β- A-β- A+β+ A-β+ P
Number 18 (17%) 23 (22%) 11 (11%) 51 (50%)  
Age 34±17 38±15 43±14 42±13 0.1
Age at diagnosis 25±17 26±12 42±12 39±12 <0.0001
Years with diabetes 9.1±10.4 9.8±8.7 0.9±3.0 3.0±4.8 <0.0001
Family history of diabetes 9 (50%) 19 (83%) 9 (82%) 45 (88%) 0.01
BMI 24.5±3.9 23.0±2.8 30.6±7.6 29.4±8.3 0.0003
Weight category         <0.0001
Lean 11 (61%) 17 (74%) 2 (18%) 17 (33%)  
Overweight 5 (28%) 6 (26%) 4 (36%) 13 (26%)  
Obese 2 (11%) 0 5 (46%) 21 (41%)  
New-onset diabetes 3 (17%) 2 (9%) 10 (91%) 26 (51%) <0.0001
Male-to-female ratio 1:1 1.3:1 0.6:1 1.7:1 0.4
Ethnicity         0.02
African American 13 (72%) 9 (39%) 4 (36.4%) 14 (27%)  
Hispanic American 2 (11%) 9 (39%) 4 (36.4%) 30 (59%)  
White American 2 (11%) 5 (22%) 3 (27.2%) 6 (12%)  
Asian American 1 (6%) 0 0 1 (2%)  
Recurrent DKA episodes 7 (39%) 7 (30%) 1 (9%) 1 (2%) <0.0001
Insulin discontinued by 6 months 0 (0%) 0 (0%) 5 (45%) 26 (51%) <0.0001
Anti-diabetic regimen at 12 months         <0.0001
Insulin only 17 (94%) 23 (100%) 3 (27%) 17 (33%)  
Insulin and oral hypoglycemics 1 (6%) 0 3 (27%) 8 (16%)  
Oral hypoglycemics only 0 0 3 (27%) 21 (41%)  
Diet and exercise only 0 0 2 (19%) 5 (10%)  
BMI: body mass index; DKA: diabetic ketoacidosis.
Reproduced with permission from: Balasubramanyam A, Nalini R, Hampe CS, Maldonado M. Syndromes of ketosis-prone diabetes mellitus. Endocr Rev 2008; 29:292. Copyright © 2008 The Endocrine Society.
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