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Principal cytochrome P450 enzymes involved in hepatic metabolism
Principal cytochrome P450 enzymes involved in hepatic metabolism
PPI
Primary pathway
Secondary pathway
Sulfotransferase
Omeprazole
CYP2C19
CYP3A4
No
Lansoprazole
CYP3A4
CYP2C19
No
Rabeprazole
CYP2C19
CYP3A4
No
Pantoprazole
CYP2C19
CYP3A4
Yes
Esomeprazole
CYP2C19
CYP3A4
No
PPI_cytochrome_metabolism.htm
PPI: proton pump inhibitor.
Adapted from: Gugler R, Jensen JC, Gastroenterology 1985; 89:1235; Diaz D, Fabre I, Daujat M, et al, Gastroenterology 1990; 99:737; Meyer UA, Eur J Gastroenterol Hepatol 1996; 8 Suppl 1:S21; Parsons ME, Eur J Gastroenterol Hepatol 1996; 8 Suppl 1:S15; Lew EA, Aliment Pharmacol Ther 1999; 13 Suppl 5:11.
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