| Upper motor neuron symptoms |
| Stiffness, slowness, and incoordination of movement |
| Hand and/or arm |
| Difficulty performing activities of daily living |
| Difficulty manipulating small objects or writing |
| Leg and/or foot |
| Gait dysfunction |
| Slow, stiff gait; difficulty turning |
| Legs "heavy" |
| Poor balance and falling |
| Spontaneous clonus |
| Spontaneous flexor spasms |
| Lower motor neuron symptoms |
| Weakness and atrophy |
| Arm and/or hand |
| Difficulty performing activities of daily living |
| Difficulty manipulating small objects or writing |
| Leg and/or foot |
| Difficulty arising from chairs or from floor |
| Difficulty climbing stairs |
| Foot drop |
| Tripping, falling |
| Fasciculations |
| Cramps |
