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Molecular classification of colorectal carcinoma

Molecular classification of colorectal carcinoma
Heredity Chromosomal instability pathway Mismatch repair pathway Serrated/CIMP pathway Hybrid pathway
Hereditary and sporadic Hereditary Hereditary and sporadic Sporadic
CIMP status Negative Negative High High Low
MSI status MSS MSI-H MSI-H MSI-L MSI-L or MSS
Chromosomal instability Present Absent Absent Absent Present
KRAS mutation +++ +/- --- --- +++
BRAF mutation --- --- +++ +++ ---
MLH1 status Normal Mutation Methylated Partial methylation Normal
MGMT methylation --- --- +/- +++ +++
Molecular_classification_of_colorectal_carcinoma.htm
CIMP: CpG island methylator phenotype; MSS: microsatellite stability; MSI: microsatellite instability; MSI-H: high-level microsatellite instability; MSI-L: low-level microsatellite instability; MGMT: O-6-methlyguanine DNA methyltransferase; +++: present; +/-: might or might not be present; ---: absent.
Noffsinger AE. Serrated polyps and colorectal cancer: New pathway to malignancy. Annu Rev Pathol 2009; 4:343. Reprinted, with permission, from the Annual Review of Pathology. Copyright © 2009 Volume 4, 2009 by Annual Reviews. www.annualreviews.org.
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