Adhesion molecule |
Cellular expression for leukocyte migration |
Integrins |
LFA-1 (CD11a/CD18b) |
Present on lymphocytes |
Mac-1 (CR3, CD11b/CD18b) |
Present on neutrophils and monocytes |
gp 150/95 (CD11c/CD18b) |
Present on neutrophils and monocytes |
VLA-4 (very late antigen-4) |
Present on lymphocytes, monocytes, and eosinophils |
Immunoglobulin superfamily |
ICAM-1 |
Low level constitutive endothelial cell expression |
Increased endothelial cell expression with stimulation |
ICAM-2 |
High level constitutive endothelial cell expression |
No increase with stimulation |
VCAM-1 |
No constitutive endothelial cell expression |
Increased endothelial cell expression with stimulation |
Selectins |
P-selectin |
Platelet and endothelial cell surface expression after stimulation |
E-selectin |
Exclusively expressed on stimulated endothelial cells |
L-selectin |
Constitutively expressed on neutrophils, monocytes, and a T cell subset |
Shed from neutrophils after stimulation with chemoattractants |