Patent ductus arteriosus in preterm infant before and after indomethacin therapy

Chest radiographs from a premature infant with a symptomatic patent ductus arteriosus (PDA) before (left panel) and after (right panel) the administration of indomethacin. Prior to therapy, the lungs are opacified due to pulmonary edema resulting from increased blood flow through the PDA; the heart is also mildly enlarged. After therapy, the lung fields are clear and heart size is smaller.