Heart failure with lisinopril versus chlorthalidone in ALLHAT

Increased relative risk of heart failure with lisinopril. Graph, with natural logarithmic scale, showing the relative risk of heart failure in all studied patients (total) and prespecified subgroups given either lisinopril or chlorthalidone in the ALLHAT study. Compared with chlorthalidone, lisinopril increased the risk of heart failure in total and in all specific subgroups.