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Uptodate Reference Title
Surfactant effect on lung pressure-volume in preterm rabbits
Surfactant effect on lung pressure-volume in preterm rabbits
Pressure-volume relationships for the inflation and deflation of surfactant-deficient and surfactant-treated preterm rabbit lungs. The control lungs are from 27-day preterm rabbits. Rabbits with surfactant deficiency have high opening pressure, low maximal volume at a distending pressure of 35 cm H2O, and the lack of deflation stability at low pressures on deflation (orange squares). In contrast, treatment of 27-day preterm rabbits with a natural surfactant alters the pressure-volume relationships with lower opening pressure, improved maximal volume at a distending pressure of 35 cm H2O, and deflation stability at low deflating pressures (green circles).
Reproduced from: Jobe AH. Lung development and maturation. In: Fanaroff & Martin's Neonatal-Perinatal Medicine - Diseases of the Fetus and Infant, 9th ed, Martin RJ, Fanaroff AA, Walsh MC (Eds), Elsevier, St. Louis 2011. Illustration used with the permission of Elsevier Inc. All rights reserved.