American Heart Association (AHA) | European Society of Cardiology (ESC) | |
Adult | Pediatric | Adult |
One of the following: Ceftriaxone¶ 2 g per 24 hours IV in one dose for 4 weeksΔ or Ampicillin◊ 2 g IV every 4 hours for 4 weeksΔ or Ciprofloxacin§ 1000 mg per 24 hours orally in two divided doses or 800 mg per 24 hours IV in two divided doses for 4 weeksΔ | Monotherapy: Ceftriaxone¶ 100 mg/kg per 24 hours IV in two divided doses, or 80 mg/kg in one daily dose (maximum dose: 4 g per 24 hours; if dose is >2 g per 24 hours, use divided dosing every 12 hours) for 4 weeksΔ or Cefotaxime 200 mg/kg per 24 hours IV in four divided doses (maximum dose: 12 g per 24 hours) for 4 weeksΔ | One of the following: Ceftriaxone¶ 2 g per 24 hours IV in one dose for 4 weeksΔ or Combination therapy with: Ampicillin◊ 12 g per 24 hours IV in six divided doses plus Gentamicin¥ 3 mg/kg per 24 hours IV or IM in two or three divided doses for 4 to 6 weeksΔ or Ciprofloxacin§ 750 mg every 12 hours orally or 400 mg every 8 or 12 hours IV for 4 weeksΔ |
Combination therapy: Ampicillin◊ 200 to 300 mg/kg per 24 hours IV divided in four or six divided doses (maximum dose: 12 g per 24 hours) for 4 weeksΔ plus Gentamicin¥ 3 to 6 mg/kg per 24 hours IV in three divided doses for 4 weeksΔ |