| High risk | Low risk |
Net state of immunosuppression |
Underlying disease |
Acute myelogenous leukemia/aplastic anemia* | + | |
Non-first remission malignancy*¶ | + | |
Chronic myelogenous leukemia, chronic phase | | + |
NeutropeniaΔ | + | |
Graft failure | + | |
CD4 cytopenia <200 cells/microL¶ | + | |
Glucocorticoids ≥1 mg/kg/day¶ | + | |
Immunomodulating viruses¶ | + | |
Age (in years)◊ |
>40Δ | + | |
<19 | | + |
Graft characteristics |
HLA relatedness |
Allogeneic matched unrelated | + | |
Allogeneic mismatched related | + | |
Allogeneic matched related | | + |
Autologous | | + |
T cell depletion |
Yes | + | |
No | | + |
CD34 infused (autologous) X 106/kg |
<2.0 | + | |
>2.5 | | + |
Conditioning regimen, allogenic |
Ablative | + | |
Reduced intensity | | + |
Organ dysfunction |
Severe mucositis◊ | + | |
Renal failure◊Δ | + | |
Graft failure◊Δ | + | |
Graft-versus-host disease§, grades II-IVΔ | + | |
Skin breakdown, breech in skin due to central venous catheter | + | |
Liver insufficiency | + | |
Lung insufficiency | + | |
Pathogen exposure |
Endogeneous: reactivation of latent infection | + | |
Exogeneous: |
Water/food/inanimate objects | + | |
Healthcare worker | + | |
Air | + | |
Donor infection | + | |