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Uptodate Reference Title
MHT increases invasive breast cancer
MHT increases invasive breast cancer
In the Women's Health Initiative (WHI), combined estrogen-progestin replacement therapy was associated with a significant increase in invasive breast cancer (unadjusted HR 1.24, 95% CI 1.01-1.54) when compared with placebo.
Data from: Chlebowski RT, Hendrix SL, Langer RD, et al. Influence of estrogen plus progestin on breast cancer and mammography in healthy postmenopausal women: The Women's Health Initiative randomized trial. JAMA 2003; 289:3243.
