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United States nonstandardized extracts: Effective and ineffective doses and major allergen content

United States nonstandardized extracts: Effective and ineffective doses and major allergen content
Allergen Effective doses* Ineffective doses* Labeling of United States nonstandardized extracts Average major allergen content
Dog (acetone precipitated) 15 mcg Can f 1 3 mcg Can f 1 1:100 w/v 140 mcg/mL Can f 1
Dog (aqueous) 15 mcg Can f 1 3 mcg Can f 1 1:10 w/v 5 mcg/mL Can f 1
Birch 3.25 to 15 mcg Bet v 1 Not determined 1:10 w/v 390 mcg/mL Bet v 1
Olive Not determined Not determined 1:10 w/v 430 mcg/mL Ole e 1
Sagebrush Not determined Not determined 1:10 w/v 1300 mcg/mL Art v 1
Alternaria alternata 1.6 and 8 mcg Alt a 1 Not determined 1:20 w/v <0.01 to 6.1 mcg/mL Alt a 1
Aspergillus fumigatus Not determined Not determined 1:20 w/v <0.01 to 64 mcg/mL Asp f 1
German cockroach Not determined Not determined 1:20 w/v 8 to 66 mcg/mL Bla g 2
w/v: weight/volume.
* Effective and ineffective doses are based upon double-blind, placebo-controlled studies.[1]
¶ Mean values. Individual lots of extracts may vary considerably from these values.[2]
References:
  1. Nelson HS. Subcutaneous injection immunotherapy for optimal effectiveness. Immunol Allergy Clin North Am 2011; 31:211.
  2. Plunkett G, ALK-Abello, Round Rock, Texas, personal communication. Values are based on analysis of dozens of extracts from all manufacturers in the US, 2011.
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