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Likelihood ratios for malignancy in solitary pulmonary nodules in men

Finding	Probability of this finding among men with:		Likelihood ratio for malignancy*
Finding	Malignant nodules	Benign nodules	Likelihood ratio for malignancy*
Diameter of nodule, cm
<1.5	0.026	0.232	0.1
1.5-2.2	0.255	0.501	0.5
2.3-3.2	0.343	0.203	1.7
3.3-4.2	0.193	0.045	4.3
4.3-5.2	0.118	0.018	6.6
5.3-6.0	0.065	0.002	29.4
Patient's age, yr
≤35	0.011	0.155	0.1
36-44	0.111	0.329	0.3
45-49	0.096	0.136	0.7
50-59	0.2	0.138	1.5
60-69	0.454	0.22	2.1
70-83	0.129	0.023	5.7
Smoking history
Never smoked	0.03	0.21	0.15
Pipe or cigar only	0.05	0.15	0.3
Ever smoked cigarettes	0.92	0.63	1.5
Current smoker or quit within past 9 yr
Average number of cigarettes per day:
1-9	0.03	0.1	0.3
10-20	0.27	0.27	1
21-40	0.38	0.19	2
≥41	0.24	0.06	3.9
Quit smoking, yr
≤3	0.07	0.05	1.4
4-6	0.04	0.04	1
7-12	0.04	0.07	0.5
≥13	0.02	0.19	0.1
Overall prevalence
Clinical settings	(0.4)		0.7•
Community surveys	(0.1)		0.1

* These likelihood ratios represent the numerator of odds that have the number 1 as the denominator (eg, 0.25:1). For simplicity, we have omitted the 1 denominator from the table.
¶ Defined as: Prevalence of malignancy/(1-Prevalence of malignancy).

Redrawn from Cummings, SR, Lillington, GA, Richard, RJ, Am Rev Respir Dis 1986; 134:449.

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