Prostatic adenocarcinoma after androgen ablation

Low-power photomicrograph of an hematoxylin- and eosin-stained tissue section of a prostate gland following androgen deprivation therapy. The scattered tumor cells have undergone cytoplasmic vacuolization and other degenerative changes (arrows). In a benign gland (arrowheads), the secretory epithelium also shows atrophic changes while basal cells are prominent.