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Placebo-controlled randomized trials of anticoagulants in acute cerebral venous thrombosis

Placebo-controlled randomized trials of anticoagulants in acute cerebral venous thrombosis
Einhäupl et al 1991, intravenous heparin versus placebo
Heparin versus placebo Outcome at three months
Heparin group (n = 10)
Total recovery 8 patients
Residual motor deficit 2 patients
Placebo group (n = 10)
Total recovery 1 patient
Minor residual deficit 6 patients
Deaths 3 patients
De Bruijn and Stam 1999, subcutaneous nadroparin versus placebo
Outcome difference Nadroparin (n = 30) Placebo (n = 29) Risk difference
At three weeks
Deaths 2 4  
BI score <15 4 3  
Death or BI <15 6 (20 percent) 7 (24 percent) 4 percent (95% CI, –25 to 17 percent)
At 12 weeks
Deaths 2 4  
Dependent (OHS 3 to 5) 2 2  
Death or dependent 4 (13 percent) 6 (21 percent) 7 percent (95% CI, –26 to 12 percent)
BI: Barthel Index; OHS: Oxford Handicap Score.
Data from:
  1. Einhäupl KM, Villringer A, Meister W, et al. Heparin treatment in sinus venous thrombosis. Lancet 1991; 338:597.
  2. de Bruijn SF, Stam J. Randomized, placebo-controlled trial of anticoagulant treatment with low-molecular-weight heparin for cerebral sinus thrombosis. Stroke 1999; 30:484.
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