Antibiotic | Adults | Children and infants >28 days old[1] |
Agent of choice: | ||
Amoxicillin-clavulanate | 875/125 mg twice daily | 7:1 formulation: 22.5 mg/kg (amoxicillin component) twice daily (maximum 875 mg amoxicillin and 125 mg clavulanate per dose) OR 4:1 formulation: 10 mg/kg (amoxicillin component) three times daily (maximum 500 mg amoxicillin and 125 mg clavulanate per dose) OR 14:1 formulation: Not ideal for this use unless clinician increases the amoxicillin component dose to 45 mg/kg twice daily¶ |
Alternate regimens includeΔ: | ||
One of the following agents with activity against Eikenella corrodens◊: | ||
Doxycycline§ | 100 mg twice daily | 1.1 to 2.2 mg/kg twice daily (maximum 100 mg per dose)¥ |
TMP-SMX§ | 1 double-strength tablet twice daily | 4 to 6 mg/kg (trimethoprim component) twice daily (maximum 160 mg trimethoprim per dose) |
Penicillin V | 500 mg four times daily | 12.5 mg/kg four times daily (maximum 500 mg per dose) |
Cefuroxime | 500 mg twice daily | 10 to 15 mg/kg twice daily (maximum 500 mg per dose) |
Ciprofloxacin | 500 to 750 mg twice daily | Use with caution in children <18 years of age‡: 10 to 20 mg/kg twice daily (maximum 750 mg per dose) |
Levofloxacin | 750 mg daily | Use with caution in children <18 years of age‡: ≥6 months old and <50 kg: 8 to 10 mg/kg twice daily (maximum 375 mg per dose) ≥50 kg: 750 mg once daily |
PLUS | ||
One of the following agents with anaerobic activity: | ||
Metronidazole | 500 mg three times daily | 10 mg/kg three times daily (maximum 500 mg per dose) |
Clindamycin§ | 300 to 450 mg three times daily | 7.5 to 10 mg/kg three times daily (maximum 600 mg per dose) |
OR | ||
Monotherapy with a fluoroquinolone: | ||
Moxifloxacin† | 400 mg daily | Not recommended; insufficient experience |