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Brain MRI (at 5, 16, and 35 months) of a patient with Sjogren-Larsson syndrome

Brain MRI (at 5, 16, and 35 months) of a patient with Sjogren-Larsson syndrome
T2-weighted MR images (3100/98 [TR/TE]). There is a delay in the maturation of the white matter on all three images.
(A) At five months of age, the unmyelinated periventricular white matter shows no abnormal signal intensities.
(B and C) Images obtained at 16 (B) and 35 (C) months of age show nonprogressive, slight signal-intensity abnormalities in the periventricular white matter that mainly involve the occipital trigones.
MRI: magnetic resonance imaging.
Reproduced with permission from: Willemsen, MA, Van Der, Graaf M, Van Der, Knaap MS, et al. MR imaging and proton MR spectroscopic studies in Sjogren-Larsson syndrome: characterization of the leukoencephalopathy. AJNR Am J Neuroradiol 2004; 25:649. Copyright ©2004 American Society of Neuroradiology.
Graphic 68733 Version 3.0