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Hypercoagulability in inflammatory bowel disease

Hypercoagulability in inflammatory bowel disease
Clinical characteristics
Unusual sites
Associated with active disease and better when disease controlled
Associated with use of steroids (possibly indicating active disease)
Recurrent
Serious
Younger age
Abnormalities described
Abnormal fibrinolysis
Abnormal platelet aggregation
Activated protein C increased
Circulating immune complexes
Decreased antithrombin III
Factor V Leiden mutation
Increased cytokines (interleukin-6, thrombopoietin)
Increased factors V and VIII
Increased plasminogen activator inhibitor
Increased sedimentation rate, fibrinogen
Lupus anticoagulant
Thrombocytosis and leukocytosis (uniformly present in most studies)
Hypercoagulability_in_IBD.htm
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