| Generalized edema |
| Increased capillary hydrostatic pressure |
| Increased plasma volume from sodium and water retention |
| Heart failure |
| (Localization can be seen in some cardiac disease) |
| Primary renal disease |
| Acute glomerulonephritis |
| Renal failure (acute/chronic) |
| Nephrotic syndrome |
| Drug induced |
| Vasodilators (eg, minoxidil) |
| Dihydropyridine calcium channel blockers (eg, nifedipine and amlodipine) |
| Venous obstruction |
| Hepatic cirrhosis |
| Decreased capillary oncotic pressure (Hypoalbuminemia) |
| Nephrotic syndrome |
| Liver failure |
| Protein losing enteropathy |
| Protein malnutrition (kwashiorkor) |
| Increased capillary permeability |
| Burn |
| Sepsis |
| Localized edema |
| Increased capillary hydrostatic pressure |
| Venous obstruction |
| Extrinsic compression (tumor or lymphadenopathy) |
| Venous thrombosis |
| Increased interstitial hydrostatic pressure |
| Lymphatic obstruction |
| Primary |
| Turner syndrome |
| Noonan syndrome |
| Milroy disease |
| Lymphedema praecox |
| Secondary |
| Lymphadenitis |
| Granulomatous lymphangitis |
| Autoimmune disease (juvenile idiopathic arthritis & Crohn disease) |
| Increased capillary permeability |
| Angioedema |
| Allergic reaction |
| Hereditary angioedema |
